Adenine diet model of kidney fibrosis
Discover a Robust and Clinically Relevant Model of Renal Fibrosis
Unlock the therapeutic potential of your compounds with our adenine diet–induced renal fibrosis model. This nutritional model faithfully mimics the progressive nature of chronic kidney disease, reproducing major hallmarks such as tubulointerstitial fibrosis, tubular atrophy, crystal deposition, and impaired renal function.
Why Choose Our Adenine Model?
- Clinically Relevant Pathophysiology: Unlike acute injury models, adenine diet feeding induces a gradual progression of CKD, closely reflecting the human disease course and providing a strong translational bridge.
- Flexible Study Design: Adjustable diet protocols (dose and duration) allow modulation of disease severity, enabling tailored proof-of-concept and long-term efficacy studies..
- Multifaceted Readouts: From renal function markers (BUN, creatinine, proteinuria) to histological, molecular, and biochemical analyses, this model offers comprehensive endpoints to evaluate anti-fibrotic and nephroprotective interventions.
- Reproducibility and Expertises: With optimized feeding regimens and dedicated monitoring, our adenine model ensures reliable induction of kidney fibrosis while minimizing variability.
By incorporating adenine into the diet, we induce chronic kidney injury through crystal deposition in renal tubules, driving inflammation and fibrosis. This robust model is particularly well-suited for long-term studies assessing not only anti-fibrotic activity but also renoprotective and disease-modifying effects.
Contact us to learn more about how we can support your research with our mouse and rat adenine diet models of renal fibrosis.
C57Bl6/J mice or aternatively on Spargue Dawley rats
Test duration up to 5 weeks, facilitating efficient evaluation of anti-fibrotic and anti-inflammatory drugs
Multiple parametric analyses, including histopathology, plasma/urine biochemistry, and gene expression evaluation
Study design
Assay readouts
