NEPHRIX Biosolutions is a highly specialized Nephrology CRO (contract research organization) committed to conducting preclinical research in the field of renal diseases.

Our research activity within renowned Universities led to the publication of many research articles and international communications dealing with the development of new in vitro and in vivo experimental tools improving the exploration of kidney and metabolic disorders. 

Screening for anti-adipogenic, pro-lipolytic and thermogenic plant extracts by models associating intestinal epithelial cells with human adipose cells.

Eur J Nutr. 2022

The hepatic compensatory response to elevated systemic sulfide promotes diabetes.

Cell Rep. 2021

Protein phosphatase 1 alpha enhances glucocorticoid receptor activity by a mechanism involving phosphorylation of serine-211.

Mol Cell Endocrinol. 2020

SGK1 activation exacerbates diet-induced obesity, metabolic syndrome and hypertension.

J Endocrinol. 2020 

Protein Phosphatase 1 Inhibitor-1 Mediates the cAMP-Dependent Stimulation of the Renal NaCl Cotransporter.

J Am Soc Nephrol. 2019

Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.

JCI Insight. 2018

Protein Phosphatase 1α enhances renal aldosterone signaling via mineralocorticoid receptor stabilization.

Mol Cell Endocrinol. 2017

Adipocyte glucocorticoid receptor has a minor contribution in adipose tissue growth.

J Endocrinol. 2016

Rab-GAP TBC1D4 (AS160) is dispensable for the renal control of sodium and water homeostasis but regulates GLUT4 in mouse kidney.

Am J Physiol Renal Physiol. 2015

Post-translational modifications of the mineralocorticoid receptor: How to dress the receptor according to the circumstances?

J Steroid Biochem Mol Biol. 2014

Hsp90 blockers inhibit adipocyte differentiation and fat mass accumulation.

PLoS One. 2014 

USP2-45 represses aldosterone mediated responses by decreasing mineralocorticoid receptor availability.

Cell Physiol Biochem. 2013

Differential ubiquitylation of the mineralocorticoid receptor is regulated by phosphorylation.

FASEB J. 2012

Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype.

Am J Physiol Renal Physiol. 2012

Mineralocorticoid receptor degradation is promoted by Hsp90 inhibition and the ubiquitin-protein ligase CHIP.

Am J Physiol Renal Physiol. 2010

Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling.

Mol Cell. 2006