In Vivo Models
In vivo proof-of-concept (POC) studies to secure your next go-to-clinic step
In addition to our in vitro assays , we validate your molecules efficacy on CKD animal models via a biochemical, molecular and physiological characterization of kidney function.
Characteristics of our in vivo services:
- Assessment of early disease markers
- High precision in tissue analyses
- Reduction of animal testing duration
- Ready-to-test or customized
Acute Kidney Injury models
- Pyelonephritis: Urinary tract infection (mice)
- Ureteral obstruction: UUO (mice & rats)
- Ischemia-Reperfusion Injury (+/- Uninephrectomy)
- Nephrotoxicity: Cisplatin (mice)
Chronic Kidney Disease models
- Diabetic Nephropathy: db/db mice or STZ rats
- Hypertension: SHR rats
- Kidney fibrosis: UUO
- Chronic infection (4 weeks)
Routine Parameters
- Blood Pressure
- GFR
- Urinary / Blood chemisry
- Food / Water intake
- Histopathology and IF imaging
- Gene / Protein expression
Radioactive tracersIsolated Perfused Kidney
Our popular models
Unilateral Ureteral Obstruction
- Surgical intervention
- Rapid CKD features
- Short duration (14 days)
- Suitable for in vivo drug screening
Ischemia Reperfusion Injury model
- Surgical intervention
- Young or aged mice
- Renal fibrosis and nephron loss
- Uni- or Bilateral ischemia
Diabetic Nephropathy STZ model
- Pharmacological intervention
- Diabetic rats or mice
- Renal fibrosis and glomerular hypertrophy
Spontaneous Hypertensive Rat model
- Genetic model
- Spontaneous hypertension
- Suitable for hypertensive drug research
Pyelonephritis
- Intra-ureteral E.Coli infusion
- Upper urinary tract infection
- Renal inflammation
- Clinically relevant
Ischemia Reperfusion + Uninephrectomy
- Surgical intervention
- Tubular alterations
- Renal inflammation
- Early stages AKI assessment
Cisplatin nephrotoxicity
- Pharmacological intervention
- Tubular and glomerular alterations
- Renal inflammation
- Single or multiple dosing