In Vivo Models

In vivo proof-of-concept (POC) studies to secure your next go-to-clinic step

In addition to our in vitro assays , we validate your molecules efficacy on CKD animal models via a biochemical, molecular and physiological characterization of kidney function.

Characteristics of our in vivo services:

  • Assessment of early disease markers
  • High precision in tissue analyses
  • Reduction of animal testing duration
  • Ready-to-test or customized

Acute Kidney Injury models

  • Pyelonephritis: Urinary tract infection (mice)
  • Ureteral obstruction: UUO (mice & rats)
  • Ischemia-Reperfusion Injury (+/- Uninephrectomy)
  • Nephrotoxicity: Cisplatin (mice)

Chronic Kidney Disease models

  • Diabetic Nephropathy: db/db mice or STZ rats
  • Hypertension: SHR rats
  • Kidney fibrosis: UUO
  • Chronic infection (4 weeks)

Routine Parameters

  • Blood Pressure
  • GFR
  • Urinary / Blood chemisry
  • Food / Water intake
  • Histopathology and IF imaging
  • Gene / Protein expression
  • Radioactive tracers
  • Isolated Perfused Kidney

Our popular models

Unilateral Ureteral Obstruction

  • Surgical intervention
  • Rapid CKD features
  • Short duration (14 days)
  • Suitable for in vivo drug screening

Ischemia Reperfusion Injury model

  • Surgical intervention
  • Young or aged mice
  • Renal fibrosis and nephron loss
  • Uni- or Bilateral ischemia

Diabetic Nephropathy STZ model

  • Pharmacological intervention
  • Diabetic rats or mice
  • Renal fibrosis and glomerular hypertrophy

Spontaneous Hypertensive Rat model

  • Genetic model
  • Spontaneous hypertension
  • Suitable for hypertensive drug research


  • Intra-ureteral E.Coli infusion
  • Upper urinary tract infection
  • Renal inflammation
  • Clinically relevant

Ischemia Reperfusion + Uninephrectomy

  • Surgical intervention
  • Tubular alterations
  • Renal inflammation
  • Early stages AKI assessment

Cisplatin nephrotoxicity

  • Pharmacological intervention
  • Tubular and glomerular alterations
  • Renal inflammation
  • Single or multiple dosing

Demonstrate the preclinical proof-of-concept of your drug in customized rodent models.