Kidney Ischemia Reperfusion Injury Model (IRI)
Discover the gold standard in Acute Kidney Injury Research, the IRI Kidney model
The Renal Ischemia Reperfusion Model is a valuable tool in preclinical research, offering several advantages for studying kidney injury and therapeutic interventions.
One key advantage of this surgical model is its relevance to clinical scenarios involving kidney ischemia reperfusion injury (IRI model), such as renal transplantation and acute kidney injury (AKI) following surgical procedures or hypovolemic shock. By inducing temporary interruption of blood flow to the kidney followed by reperfusion, this model mimics the pathophysiological processes seen in these conditions, allowing researchers to investigate the underlying mechanisms and test potential treatments.
We propose validated in vivo models that allow longitudinal studies, as the extent of renal injury and functional recovery can be monitored over time using various techniques such as histology, biomarker analysis, and functional assays. We offer different types of surgical procedures:
- Unilateral Ischemia Reperfusion Injury (uIRI)
- Uninephrectomy + Ischemia Reperfusion Injury (Ux/IRI)
- Bilateral Ischemia Reperfusion Injury (bIRI)
Contact us to learn more about how we can support your scientific endeavors with our rat ou mouse iri models.
2-3 days for the Ux/IRI (acute effects) to 4 weeks for the uIRI (chronic effects) allowing a longitudinal evaluation of therapeutic compounds
Study design uIRI
Assay readouts
