In vitro Preclinical Services
Validate new leads and secure your next go-to in vivo step
Based on our in vitro assays platform, we assess new molecules from your libraries by testing their nephrotoxicity and efficacy (on selected parameters) within a month. Exploration of molecular mechanisms validation are guided by Go/No-Go decisions.
Characteristics of our innovative solutions :
- Shows >80% of physiological features
- High level of drug effects prediction
- Modulable micro-environment
- Reduction of animal tests failures and costs
At NEPHRIX Biosolutions, we provide a comprehensive portfolio of cellular models tailored to diverse research needs.
In Vitro Assays
We optimized a panel of in vitro fibrosis assays using human primary fibroblasts (Renal, Liver, Lung, Cardiac and Skin) enabling the evaluation of pro-fibrotic related markers : i.e. fibronectin, α-SMA expression, or extra-cellular matrix secretion.
Read more about the Fibrosis Assay…
DuoXProx™, the kidney-specific co-culture model, combines proximal tubular cells and renal fibroblasts in optimized medium within a single system, enabling the evaluation of fibrosis-related parameters while reproducing the cellular crosstalk driving pathological remodelling.
Read more about our Kidney Fibrosis Assay…
Using human whole blood cells or isolated immune cells, our inflammation assay enables controlled testing of inflammatory responses and potential effects of anti-inflammatory molecules for predictive outcomes.
Read more about our Inflammation Assay…
Our assay evaluate the different parameters of aging-associated cell dysfunction (SA-beta-Galactosidase assay, SASP, respiration…) and evaluate anti-aging or therapeutic interventions.
Read more about our Senescence Assay…
Why choose NEPHRIX Biosolutions?
Scientific Expertise
Clinically Relevant Models
Flexible Study Design
Multi-parameters Readouts
Why choose NEPHRIX Biosolutions?
Scientific Expertise
Clinically Relevant Models
Flexible Study Design
Multi-parameters Readouts