In vitro preclinical services
Validate new molecules and secure your next go-to in vivo step with our CRO
Using our in vitro models, we assess new leads from your libraries by testing their nephrotoxicity and efficacy (on selected parameters) within a month.
Exploration of molecular mechanisms or in vivo validation are guided by Go/No-Go decisions.
Characteristics of our innovative solutions :
- Shows >80% of physiological features
- High level of drug effects prediction
- Modulable micro-environment
- Reduction of animal tests failures and costs
Cell types
Podocytes
Mesangial
Tubular cells (proximal, TAL, distal)
Endothelial
Fibroblasts
more ...
Environment
Inflammatory
Hyperglycemic
Fibrotic
Hypoxic
Drug toxicity
more ...
Parameters
Cell death &
membrane leakage
Epithelium integrity
Mitochondrial activity
Gene & Protein expression
Channel & transporter function
more ...
Popular in vitro models
Fibrosis Assays
Our in vitro fibrosis assays allow controlled evaluation of drug efficacy on the transition of Fibroblasts to Myofibroblasts.
Read more about our Fibrosis Assay, or the DuoXProx™ fibrosis assay...
Inflammation assay
Our inflammation assay enables controlled testing of inflammatory responses and potential effects of anti-inflammatory molecules for predictive outcomes.
Read more about our Inflammation Assay…,
Senescence assay
This assay evaluate the different parameters of aging-associated cell dysfunction and evaluate anti-aging or therapeutic interventions.
Read more about our Senescence Assay…,
Why choose NEPHRIX Biosolutions?
Scientific Expertise
Predictive Preclinical Models
Flexible and Customizable Services
Dedicated Support
Why choose NEPHRIX Biosolutions?
Scientific Expertise
Predictive Preclinical Models
Flexible and Customizable Services
Dedicated Support