Kidney Ischemia Reperfusion Injury Model
Discover the Gold Standard in Acute Renal Injury Research
The Renal Ischemia Reperfusion Mouse Model is a valuable tool in preclinical research, offering several advantages for studying kidney injury and therapeutic interventions. One key advantage of this surgical model is its relevance to clinical scenarios involving kidney ischemia reperfusion injury (IRI), such as renal transplantation and acute kidney injury (AKI) following surgical procedures or hypovolemic shock. By inducing temporary interruption of blood flow to the kidney followed by reperfusion, this model mimics the pathophysiological processes seen in these conditions, allowing researchers to investigate the underlying mechanisms and test potential treatments. Our CRO proposes validated in vivo models allow longitudinal studies, as the extent of renal injury and functional recovery can be monitored over time using various techniques such as histology, biomarker analysis, and functional assays. We offer different type of surgical procedures:- Unilateral Ischemia Reperfusion Injury (uIRI)
- Uninephrectomy + Ischemia Reperfusion Injury (Ux/IRI)
- Bilateral Ischemia Reperfusion Injury (bIRI)
Usually C57Bl6/J mice but possible aternative on Spargue Dawley rats
2-3 days for the Ux/IRI (acute effects) to 4 weeks for the uIRI (chronic effects) allowing a longitudinal evaluation of therapeutic compounds
Multiple parametric analyses, including histopathology, biochemistry, and gene expression studies
Study design uIRI
Assay readouts
