Kidney Diseases Animal Models
In addition to our in vitro assays , we validate your molecules efficacy on CKD or AKI in vivo models via a biochemical, molecular and physiological characterization of kidney function.
Take advantage from our expertise in measuring the Glomerular Filtration Rate (GFR) using transdermal technology for sensitive and non-invasive kidney function measurement during treatment protocol.
Characteristics of our in vivo services:
- Assessment of early disease markers
- High precision in tissue analyses
- Reduction of animal testing duration
- Ready-to-test or customized
Our popular models
Unilateral Ureteral Obstruction
- Surgical intervention
- Rapid CKD features
- Short duration (14 days)
- Suitable for in vivo drug screening
Ischemia Reperfusion Injury model
- Surgical intervention
- Young or aged mice
- Renal fibrosis and nephron loss
- Uni- or Bilateral ischemia
Diabetic Nephropathy STZ model
- Pharmacological intervention
- Diabetic rats or mice
- Renal fibrosis and glomerular hypertrophy
Spontaneous Hypertensive Rat model
- Genetic model
- Spontaneous hypertension
- Suitable for hypertensive drug research
Pyelonephritis
- Intra-ureteral E.Coli infusion
- Upper urinary tract infection
- Renal inflammation
- Clinically relevant
Ischemia Reperfusion + Uninephrectomy
- Surgical intervention
- Tubular alterations
- Renal inflammation
- Early stages AKI assessment
Cisplatin nephrotoxicity
- Pharmacological intervention
- Tubular and glomerular alterations
- Renal inflammation
- Single or multiple dosing