In vivo proof-of-concept studies to secure your next go-to-clinic step

In addition to our in vitro tests, we validate your molecules efficacy on CKD animal models via a biochemical, molecular and physiological characterization of kidney function.

Characteristics of our in vivo solutions:

  • Assessment of early disease markers
  • High precision in tissue analyses
  • Reduction of animal testing duration
  • Ready-to-test or customized

Acute Kidney Injury models

  • Pyelonephritis: Urinary tract infection (mice)
  • Ureteral obstruction: UUO (mice & rats)
  • Ischemia-Reperfusion Injury (+/- Uninephrectomy)
  • Nephrotoxicity: Cisplatin (mice)

Chronic Kidney Disease models

  • Diabetic Nephropathy: db/db mice or STZ rats
  • Hypertension: SHR rats
  • Kidney fibrosis: UUO
  • Chronic infection (4 weeks)

Routine Parameters

  • Blood Pressure
  • GFR
  • Urinary / Blood chemisry
  • Food / Water intake
  • Histopathology and IF imaging
  • Gene / Protein expression
  • Radioactive tracers
  • Isolated Perfused Kidney

Demonstrate the preclinical proof-of-concept of your drug in customized rodent models.