In vivo proof-of-concept studies to secure your next go-to-clinic step
In addition to our in vitro tests, we validate your molecules efficacy on CKD animal models via a biochemical, molecular and physiological characterization of kidney function.
Characteristics of our in vivo solutions:
- Assessment of early disease markers
- High precision in tissue analyses
- Reduction of animal testing duration
- Ready-to-test or customized
Acute Kidney Injury models
- Pyelonephritis: Urinary tract infection (mice)
- Ureteral obstruction: UUO (mice & rats)
- Ischemia-Reperfusion Injury (young & aged mice)
- Nephrotoxicity: Cisplatin (mice)
Chronic Kidney Disease models
- Diabetic Nephropathy: db/db mice
- ADPKD: pkd2ws25/− (Yale University)
- Hypertension: SHR rats
- Kidney fibrosis: UUO
- Chronic infection (4 weeks)
Routine Parameters
- Blood Pressure
- GFR
- Urinary / Blood chemisry
- Food / Water intake
- Histopathology and IF imaging
- Gene / Protein expression
Radioactive tracersIsolated Perfused Kidney