Unilateral Ureteral Obstruction (UUO)

  • Home
  • Unilateral Ureteral Obstruction (UUO)

Unilateral Ureteral Obstruction model of kidney fibrosis (UUO)

Discover the Gold Standard in Renal Fibrosis Research

Unlock the anti-fibrotic potential of your compounds with our Unilateral Ureteral Obstruction (UUO) model. Widely used as a premier model for assessing renal fibrosis, UUO reproduces key pathological hallmarks of chronic kidney disease, including interstitial fibrosis, tubular atrophy, and inflammatory cell infiltration.

Why Choose Our UUO Model? 

  • Proven Efficacy: Backed by extensive research, our UUO model consistently delivers reliable results, empowering researchers to validate a first proof-of-concept in kidney fibrosis.
  • Optimized Test Duration: With a concise test duration of just 1 or 2 weeks, our UUO model streamlines in vivo screening tests for anti-fibrotic drugs, saving time and resources without compromising accuracy.
  • Comprehensive Analysis: Experience complete insights with our comprehensive analysis approach. From histopathology to biochemistry and gene expression studies, our model facilitates multi-faceted investigations, maximizing data yield from each experimental subject.

Our surgical procedure ensures precision and reproducibility at every step. Through precise ligation of one side of the ureter, we induce targeted disease pathology while minimizing procedural variability. Subsequently, the diseased kidney is meticulously divided into three sections, enabling thorough analysis across various modalities. From histopathological assessments to biochemical assays and gene expression profiling, our UUO model offers an efficient tool to explore renal fibrosis progression.

Contact us to learn more about how we can support your scientific endeavors with our mice models and rats models of UUO.

Preclinical Cro- UUO Model

Usually C57Bl6/J mice but possible aternative on Spargue Dawley rats

test duration up to 2 weeks, facilitating rapid in vivo screening tests for anti-fibrotic drugs

multiple parametric analyses, including histopathology, biochemistry, and gene expression studies

Study design

UUO model

Assay readouts

Renal Fibrosis model - UUO Model